The Role of Biofilms in Device-Related Infections (Springer Series on Biofilms)
by Mark Shirtliff, Jeff Leid
The Role of Biofilms in Device-Related Infections (Springer Series on Biofilms)
By Mark Shirtliff, Jeff Leid
Publisher: Springer
Number Of Pages: 273
Publication Date: 2008-12-01
ISBN-10 / ASIN: 3540681132
ISBN-13 / EAN: 9783540681137
Binding: Hardcover
Approximately 60% of all hospital-associated infections, over one
million cases per year, are due to biofilms that have formed on
indwelling medical devices. Device-related biofilm infections increase
hospital stays and add over one billion dollars/year to U.S.
hospitalization costs. Since the use and the types of indwelling
medical devices commonly used in modern healthcare are continuously
expanding, especially with an aging population, the incidence of
biofilm infections will also continue to rise. The central problem with
microbial biofilm infections of foreign bodies is their propensity to
resist clearance by the host immune system and all antimicrobial agents
tested to date. In fact, compared to their free floating, planktonic
counterparts, microbes within a biofilm are 50 鈥?500 times more
resistant to antimicrobial agents. Therefore, achieving therapeutic and
non-lethal dosing regimens within the human host is impossible. The end
result is a conversion from an acute infection to one that is
persistent, chronic, and recurrent, most often requiring device removal
in order to eliminate the infection. This text will describe the major
types of device-related infections, and will explain the host,
pathogen, and the unique properties of their interactions in order to
gain a better understanding of these recalcitrant infections.
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http://ifile.it/r8nlkj9
http://ifile.it/r8nlkj9/The%20Role%20of%20Biofilms%20in%20device%20related%20infections.pdf
by Mark Shirtliff, Jeff Leid
The Role of Biofilms in Device-Related Infections (Springer Series on Biofilms)
By Mark Shirtliff, Jeff Leid
Publisher: Springer
Number Of Pages: 273
Publication Date: 2008-12-01
ISBN-10 / ASIN: 3540681132
ISBN-13 / EAN: 9783540681137
Binding: Hardcover
Approximately 60% of all hospital-associated infections, over one
million cases per year, are due to biofilms that have formed on
indwelling medical devices. Device-related biofilm infections increase
hospital stays and add over one billion dollars/year to U.S.
hospitalization costs. Since the use and the types of indwelling
medical devices commonly used in modern healthcare are continuously
expanding, especially with an aging population, the incidence of
biofilm infections will also continue to rise. The central problem with
microbial biofilm infections of foreign bodies is their propensity to
resist clearance by the host immune system and all antimicrobial agents
tested to date. In fact, compared to their free floating, planktonic
counterparts, microbes within a biofilm are 50 鈥?500 times more
resistant to antimicrobial agents. Therefore, achieving therapeutic and
non-lethal dosing regimens within the human host is impossible. The end
result is a conversion from an acute infection to one that is
persistent, chronic, and recurrent, most often requiring device removal
in order to eliminate the infection. This text will describe the major
types of device-related infections, and will explain the host,
pathogen, and the unique properties of their interactions in order to
gain a better understanding of these recalcitrant infections.
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