Multiple Aspects of DNA
and RNA: from Biophysics to Bioinformatics (Lecture Notes of the Les
Houches Summer School 2004, Volume Session LXXXII)
Multiple Aspects of DNA and RNA: from Biophysics to Bioinformatics,
Volume Session LXXXII: Lecture Notes of the Les Houches Summer School
2004 (Les Houches)
By Didier Chatenay, Simona Cocco, Remi Monasson, Denis Thieffry, Jean Dalibard
Publisher: Elsevier Science
Number Of Pages: 378
Publication Date: 2005-12-19
ISBN-10 / ASIN: 0444520813
ISBN-13 / EAN: 9780444520814
Binding: Hardcover
This book is dedicated to the multiple aspects, that is,
biological, physical and computational of DNA and RNA molecules. These
molecules, central to vital processes, have been experimentally studied
by molecular biologists for five decades since the discovery of the
structure of DNA by Watson and Crick in 1953. Recent progresses (e.g.
use of DNA chips, manipulations at the single molecule level,
availability of huge genomic databases...) have revealed an imperious
need for theoretical modelling. Further progresses will clearly not be
possible without an integrated understanding of all DNA and RNA aspects
and studies.
The book is intended to be a desktop reference for advanced
graduate students or young researchers willing to acquire a broad
interdisciplinary understanding of the multiple aspects of DNA and RNA.
It is divided in three main sections:
The first section comprises an introduction to biochemistry and
biology of nucleic acids. The structure and function of DNA are
reviewed in R. Lavery's chapter. The next contribution, by V. Fritsch
and E. Westhof, concentrates on the folding properties of RNA
molecules. The cellular processes involving these molecules are
reviewed by J. Kadonaga, with special emphasis on the regulation of
transcription. These chapters does not require any preliminary
knowledge in the field (except that of elementary biology and
chemistry).
The second section covers the biophysics of DNA and RNA,
starting with basics in polymer physics in the contribution by R.
Khokhlov. A large space is then devoted to the presentation of recent
experimental and theoretical progresses in the field of single molecule
studies. T. Strick's contribution presents a detailed description of
the various micro-manipulation techniques, and reviews recent
experiments on the interactions between DNA and proteins (helicases,
topoisomerases, ...). The theoretical modeling of single molecules is
presented by J. Marko, with a special attention paid to the elastic and
topological properties of DNA. Finally, advances in the understanding
of electrophoresis, a technique of crucial importance in everyday
molecular biology, are exposed in T. Duke's contribution.
The third section presents provides an overview of the main
computational approaches to integrate, analyse and simulate molecular
and genetic networks. First, J. van Helden introduces a series of
statistical and computational methods allowing the identification of
short nucleic fragments putatively involved in the regulation of gene
expression from sets of promoter sequences controlling co-expressed
genes. Next, the chapter by Samsonova et al. connects this issue of
transcriptional regulation with that of the control of cell
differentiation and pattern formation during embryonic development.
Finally, H. de Jong and D. Thieffry review a series of mathematical
approaches to model the dynamical behaviour of complex genetic
regulatory networks. This contribution includes brief descriptions and
references to successful applications of these approaches, including
the work of B. Novak, on the dynamical modelling of cell cycle in
different model organisms, from yeast to mammals.
. Provides a comprehensive overview of the structure and function of
DNA and RNA at the interface between physics, biology and information
science.
http://www.filefactory.com/file/bfabbc/n/0444520813_rar
and RNA: from Biophysics to Bioinformatics (Lecture Notes of the Les
Houches Summer School 2004, Volume Session LXXXII)
Multiple Aspects of DNA and RNA: from Biophysics to Bioinformatics,
Volume Session LXXXII: Lecture Notes of the Les Houches Summer School
2004 (Les Houches)
By Didier Chatenay, Simona Cocco, Remi Monasson, Denis Thieffry, Jean Dalibard
Publisher: Elsevier Science
Number Of Pages: 378
Publication Date: 2005-12-19
ISBN-10 / ASIN: 0444520813
ISBN-13 / EAN: 9780444520814
Binding: Hardcover
This book is dedicated to the multiple aspects, that is,
biological, physical and computational of DNA and RNA molecules. These
molecules, central to vital processes, have been experimentally studied
by molecular biologists for five decades since the discovery of the
structure of DNA by Watson and Crick in 1953. Recent progresses (e.g.
use of DNA chips, manipulations at the single molecule level,
availability of huge genomic databases...) have revealed an imperious
need for theoretical modelling. Further progresses will clearly not be
possible without an integrated understanding of all DNA and RNA aspects
and studies.
The book is intended to be a desktop reference for advanced
graduate students or young researchers willing to acquire a broad
interdisciplinary understanding of the multiple aspects of DNA and RNA.
It is divided in three main sections:
The first section comprises an introduction to biochemistry and
biology of nucleic acids. The structure and function of DNA are
reviewed in R. Lavery's chapter. The next contribution, by V. Fritsch
and E. Westhof, concentrates on the folding properties of RNA
molecules. The cellular processes involving these molecules are
reviewed by J. Kadonaga, with special emphasis on the regulation of
transcription. These chapters does not require any preliminary
knowledge in the field (except that of elementary biology and
chemistry).
The second section covers the biophysics of DNA and RNA,
starting with basics in polymer physics in the contribution by R.
Khokhlov. A large space is then devoted to the presentation of recent
experimental and theoretical progresses in the field of single molecule
studies. T. Strick's contribution presents a detailed description of
the various micro-manipulation techniques, and reviews recent
experiments on the interactions between DNA and proteins (helicases,
topoisomerases, ...). The theoretical modeling of single molecules is
presented by J. Marko, with a special attention paid to the elastic and
topological properties of DNA. Finally, advances in the understanding
of electrophoresis, a technique of crucial importance in everyday
molecular biology, are exposed in T. Duke's contribution.
The third section presents provides an overview of the main
computational approaches to integrate, analyse and simulate molecular
and genetic networks. First, J. van Helden introduces a series of
statistical and computational methods allowing the identification of
short nucleic fragments putatively involved in the regulation of gene
expression from sets of promoter sequences controlling co-expressed
genes. Next, the chapter by Samsonova et al. connects this issue of
transcriptional regulation with that of the control of cell
differentiation and pattern formation during embryonic development.
Finally, H. de Jong and D. Thieffry review a series of mathematical
approaches to model the dynamical behaviour of complex genetic
regulatory networks. This contribution includes brief descriptions and
references to successful applications of these approaches, including
the work of B. Novak, on the dynamical modelling of cell cycle in
different model organisms, from yeast to mammals.
. Provides a comprehensive overview of the structure and function of
DNA and RNA at the interface between physics, biology and information
science.
http://www.filefactory.com/file/bfabbc/n/0444520813_rar
